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Arch Virol ; 166(8): 2299-2303, 2021 Aug.
Artículo en Inglés | MEDLINE | ID: covidwho-1260595

RESUMEN

Nucleic acid testing and antibody testing data from 143 recovered COVID-19 patients during the convalescent phase were retrospectively analyzed. A total of 23 (16.1%) recovered patients re-tested positive for SARS-CoV-2 RNA by RT-PCR. Three months after symptom onset, 100% and 99.3% of the patients remained positive for total and IgG antibodies, and the antibody levels remained high. IgM antibodies declined rapidly, with a median time to seroconversion of 67 (95% CI: 59, 75) days after onset. Approximately 25% of patients were seronegative for IgA antibodies at three months after onset. There was no statistically significant difference in antibody kinetics between patients with and without re-positive RT-PCR results during the convalescent phase.


Asunto(s)
Anticuerpos Antivirales/sangre , COVID-19/inmunología , Convalecencia , SARS-CoV-2/inmunología , Adulto , COVID-19/diagnóstico , Prueba de COVID-19 , Femenino , Humanos , Inmunoglobulina A/sangre , Inmunoglobulina G/sangre , Inmunoglobulina M/sangre , Cinética , Masculino , Persona de Mediana Edad , ARN Viral/genética , Estudios Retrospectivos , SARS-CoV-2/genética , SARS-CoV-2/aislamiento & purificación , Seroconversión
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